Conclusions: Excessive Zn intake may be a factor to elevate systemic BP levels in a normotensive state presumably through the oxidative stress caused by superoxide.
Effects of Zinc on Blood Pressure
If enough zinc is not circulating throughout your bloodstream, your blood pressure may increase, according to a 2005 study published in the journal "Pediatric Research." Researchers discovered that even a mild zinc deficiency can have a significant impact on arterial blood pressure. Having a zinc deficiency while you are young and your body is still growing may increase your risk of developing cardiovascular disease later in life.
While having a zinc deficiency can damage your cardiovascular system, excess zinc can also elevate your blood pressure. In a 2004 study published in the "Journal of Hypertension," researchers discovered that excess zinc intake influences systolic blood pressure and mean arterial pressure. The researchers conclude that getting too much zinc in your diet can cause a hypertensive state by increasing the oxidative stress placed on your arteries.
Zinc and Copper
Zinc interacts with other minerals, especially copper, to influence blood pressure, according to a study published in the "Journal of Trace Elements in Medicine and Biology." In this study, zinc and copper were found to be interrelated, and when these two minerals are out of sync with each other, blood pressure is adversely affected. The researchers state that imbalances between zinc and copper in your body may be associated with an increased risk of hypertension, or high blood pressure.
Because a zinc deficiency or excess zinc can have adverse effects on your blood pressure, it is important to make sure you are getting the right amount of zinc in your diet. The recommended dietary allowance, or RDA, for zinc in adult men is 11 mg per day, while adult women require 8 mg. However, the amount of zinc you need depends on a variety of factors, including age, disease and pregnancy. Talk with your physician before taking zinc supplements for health.
Zinc, an essential micronutrient, affects the heart by modulating cardiomyocyte oxidative stress and maintaining myocardial structure, among other mechanisms. In cross-sectional studies, patients with heart failure have often had zinc deficiencies, suggesting effects on the ongoing pathogenesis of heart failure.
Medications that may interfere with zinc include: blood pressure medications, penicillamine, amiloride, certain antibiotics, ACE inhibitors, cisplatin, immunosuppressant medications, deferoxamine, nonsteroidal anti-inflammatory drugs (NSAIDs) and thiazide diuretics.
The National Institutes of Health considers 40 mg of zinc a day to be the upper limit dose for adults and 4 mg of zinc a day for infants under age 6 months.