Can driving cause high blood pressure? Hours sitting behind the wheel and eating meals on the fly can result in high blood pressure, which is a condition that affects both the health and well-being of many truckers and their ability to drive. However, blood pressure is manageable. What blood pressure is too high while driving? They require the systolic pressure (top reading) to be Less than 180. Furthermore, the diastolic (bottom reading) needs to be less than 100 also. The DVLA form does ask is it consistently higher than 180/100.