High pressure in the portal vein can be caused by various factors, including liver scarring (cirrhosis), liver cancer, and tumors that block or narrow the portal vein. In addition to cirrhosis, several other medical conditions are associated with high blood pressure in the portal veins, including: * Liver cancer: In some cases, liver cancer can cause blockages in the portal vein, leading to increased blood pressure. * Tumors: Growths or tumors in the abdomen, particularly those near the portal vein, can compress or obstruct it, causing elevated blood pressure. If you're experiencing symptoms like pain, fatigue, or abdominal swelling, consult a doctor. They may recommend diagnostic tests such as imaging studies (e.g., ultrasound or CT scans) and blood tests to determine the underlying cause of high pressure in your portal vein.