The ONE organ responsible for high blood pressure.
Thiazide diuretics: What you need to know
What are thiazide diuretics? Thiazide diuretics are a type of diuretic (a drug that increases urine flow). They act directly on the kidney and promote diuresis (urine flow) by inhibiting the sodium/chloride cotransporter located in the distal tubule of the nephron (a functional unit of the kidney). Thiazides reduce sodium reabsorption, which increases urinary fluid loss, which in turn reduces extracellular fluid and plasma volume. This reduces cardiac output (how hard the heart has to work to pump blood through the body) and lowers blood pressure. Thiazides also work in other ways to lower blood pressure. Thiazides also cause a loss of potassium while retaining calcium. Thiazides are typically used to lower blood pressure because their diuretic effect is relatively weak compared to other types of diuretics (such as loop diuretics). Examples of thiazide diuretics taken orally include:
What are the trade names of thiazide diuretics?
Three thiazide diuretics are most commonly used: hydrochlorothiazide (HCTZ), chlortalidone and indapamide. HCTZ and chlortalidone are FDA-approved for clinical use in the treatment of primary hypertension.
Which thiazide diuretic is best?
Chlortalidone is the preferred diuretic for initial and continuing therapy of hypertension, starting at a dose of 12.5 mg/d and increasing to ≤25.0 mg/d with or without other antihypertensive drugs.
What medications should not be taken with thiazide diuretics?
Most thiazide diuretics are taken once a day, in the morning. Any reduction in blood pressure is maintained for 24 hours with this once-a-day dose. However, the effect of the extra urine is used up within 12 hours. So you won't have to get up at night to make extra trips to the toilet. The dose used to treat high blood pressure (hypertension) is quite low and many people hardly notice the increase in urine output.